2017 Q2 Newsletter

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Research Update
 
In our hearts and #1 in our mission is a desire to eradicate Ewing Sarcoma.  Despite many years of clinical trials using different combinations of chemotherapy, many diagnosed with Ewing sarcoma are not cured of the disease, especially when the cancer is at an advanced stage when diagnosed. Ewing sarcomas are caused when pieces of two different chromosomes fuse together abnormally, creating a fusion gene known as EWS-FLI1 that is the main driver of tumor growth. However, no treatments currently target EWS-FlI1 specifically. 

More than a year ago, 1 Million 4 Anna funding established a Ewing Sarcoma Research Program at UT Southwestern Medical Center in Dallas.  This collaborative, multi-focal attack using the complementary expertise of different research groups is committed to discovering new treatments for Ewing sarcoma that are more effective and less toxic than current therapies. While the disease’s genetic origin is known, understanding how the disease progresses and identifying ways to fight the tumors early on, at their genetic origins, is one goal of this team.
 
Progress has been made in some key areas. Dr. Ralph DeBerardinis’s lab has made the first map of the cellular energy pathways of Ewing sarcoma cells. Understanding precisely how EWS-FLI1 reprograms the cell’s energy supply to support tumor progression is a key first step to finding new ways to prevent the growth of Ewing sarcomas. Dr. Ralf Kittler’s team has used insights from their work on prostate cancer to identify a promising approach that might be able to trigger destruction of EWS-FLI1 in cancer cells, leading to a halt in cell growth. Dr. David McFadden’s lab has engineered Ewing sarcoma cell lines to create a rigorous system for high-throughput screening of molecules that could form the basis of new Ewing sarcoma therapies. Taking a complementary approach using zebrafish models of Ewing sarcoma, Dr. James Amatruda’s group has identified a new cell signaling pathway that appears to represent a target of vulnerability for Ewing sarcoma tumors. Dr. Angelique Whitehurst’s lab studies proteins that are not present in normal cells but that are turned on in cancer cells. They have found one such protein in Ewing sarcoma cells and have shown that it is required for growth of the tumor cells. This protein appears to function in the same pathway identified by the Amatruda group using the fish model. The possibilities for crossover and cooperation between the different labs is one of the most exciting aspects of the UTSW initiative. In the coming year we’re looking forward to more progress as the work in all five labs continues and the focus on Ewing sarcoma is kept at the forefront.  

                      
 From left to right: Dr. Amatruda, Dr. DeBerardinis, Dr. Whitehurst, Dr. Kittler, Dr. McFadden

We are grateful for the expertise and commitment of this passionate team working hard to improve treatment for this complicated and devastating disease. 

We would also like to thank the Nick Teddy Foundation for their support of Dr. Amatruda’s team again this year. We are stronger together.
Georgia Golf Tournament and Dinner
 
It was a beautiful day in Johns Creek, Georgia on Monday April 10th – the day of the 1M4A Inaugural Georgia Golf Tournament & Dinner! We welcomed 92 golfers and 200 for dinner at the Country Club of the South.  We are excited to share that we raised nearly $75,000 for our mission – “To win the fight against Ewing sarcoma today, tomorrow, and until it’s gone!” Thank you to everyone who helped make this wonderful day and evening come together. 
 
After warm-ups, lunch, welcome, and of course “Float On” – the golfers were off at 12:12 p.m.  The course was full of volunteers making the day extra fun for everyone.  We enjoyed having Carolyn and Brylie, two ewing sarcoma survivors, with us during the day to meet and greet everyone, and sweet Brylie led us in prayer before dinner. 
 
The ballroom was packed for the evening program led by Emcee, Elizabeth Dulin, and highlighted by guest speakers, Dr. Thomas Cash, Pediatric Oncologist with Children’s Healthcare of Atlanta, and 16 year old Ewing’s survivor, Maddie Harris. We enjoyed bringing together our honored guests - nine families - all whose lives have been affected by ewing sarcoma. Our bond and are time together so meaningful.


From left to right: Carolyn, Brylie with Dr. John Hull, David & Carol with Dr. Cash, and Maddie with her brother Nathan. 

Grateful for these special families, united in the fight against Ewing sarcoma. 

Congratulations to Arthur Gopfert, Joe Jarrard, Dalton Humphry, Drew Long – the champions of the 1 Million 4 Anna Inaugural Georgia Golf Tournament!!
 
Enormous thanks to Laurie Goacher, Golf Tournament Chair, and the planning committee:  Jennifer Brattain, Kristi Buce, Janet Cutcliff, Lindsey Cutcliff, Allison Downing, Toni Flory, Julie Greenfield, Susan Hart, Sharon Hull, MaryAnne Koutrelakos, Judi Kuelbs, Sandy Lamb, Teresa Lopez, Mary Alice McDowell, Kim McGill, Christel Morrison, Robin Myers, Cheryl Pinion, Jennifer Ponseigo, Anita Pursley, Christi Ratté, Karen Selembo, Cheri Skop, Sara Wagoner, and Donna Weigle.
    
 
 
Chili Cook-Off

We participated again in the Young Texans Against Cancer’s Annual Chili Cook-Off.  The 1M4A team enjoyed the fun day with the crowd at The Foundry in Dallas while presenting and sharing David’s famous chili!! Thanks to YTAC for all you do in the fight against cancer and for supporting 1M4A! We’ll be back next year, hoping to redeem ourselves after not placing… Thank you Quinn, Zach, Krissy, Carly, and Becca for representing 1M4A!
 

 
Recent Events

Jillian Williams and her Mom, Janna, worked with their TX State Representative to have March 1st declared Childhood Cancer Awareness Day at the Texas State Capitol.  We attended with Jillian’s family and friends, her medical team from South Texas Pediatric Blood & Cancer Center in San Antonio, and other foundations.  Awareness is key! Jillian is a new 1M4A Scholarship Recipient and is returning to school this fall! She is also the guest speaker at our 6th Annual Celebration Dinner being held in Dallas on September 24th.  
 


Taylor Horn represented 1M4A at the Young Texan’s Against Cancer STRUT Event in February.  Taylor is a four year 1M4A Scholarship recipient studying Nursing and is 14 years N.E.D.!!  STRUT stands for Striving to Resolve, Unite and Triumph in the fight against cancer and all the models are cancer survivors.
More Thank Yous
 
Thank you Emily for your support of Anna’s Closets in Georgia!
 

Thank you Avery for continuing to support Anna’s Closets for the past FOUR years!
 

Thank you to the Lutheran Sports Association of Missouri (LSAM) for collecting donations at their annual basketball tournament. We are appreciative of your support and generous donation!
 
Sean Karl Foundation
For friends in Tennessee and the southeast - please check out the Sean Karl Foundation and their events.  The Sean Karl Foundation was founded in loving memory of Sean Karl, a brave young man who also battled ewing sarcoma.  The mission of the Sean Karl Foundation is to defeat Ewing Sarcoma by raising necessary research funds to fight this disease. Their secondary focus is to raise awareness of the insufficient funding of pediatric cancer as a whole.  We have had the honor of meeting some of the members of their team of volunteers, who are bound by their love for Sean and passionate about making a difference.  Please check out their website and Facebook page.


Loved our time with Hunter, of the Sean Karl Foundation, sharing memories of Sean and Anna.


Great Nonprofits
When you have a moment, please check out our reviews on greatnonprofits.org.  Feel free to add one of your own! This site is used to find and review charities for volunteering, donation, and grant opportunities.  Thank you!!!

VIP Updates

Maddie is now 2 ½ years N.E.D.!  She recently had surgery to improve the range of motion in her arm and is recovering.  She’s happy, making awesome grades, and heading back to Camp iHope in June.  We’re lucky we get to see her on frequent family trips to Dallas!
 
Zachary is doing well. He just recently celebrated his 10th birthday! He’s now finished with PT and walking well. He’s learning to box and is swimming competitively. Zachary and his family recently traveled to Spain for his Make-A-Wish trip. 
 
Alexander is almost two months out of treatment and is making up for lost time – staying super busy and having loads of fun! His port is out and his hair is growing back quickly! Alex threw out the ceremonial first pitch at the Frisco Roughriders Game yesterday!
Upcoming Events
 
5/5 - Cinco de Mayo event in Mokena, IL in memory of Kristi Sewing. 
5/5 - Queso Bowl in San Antonio, hosted by the YTAC San Antonio Chapter.  1M4A is one of their benefactors
 
6/3 - "Art Around Adams" San Diego, CA  http://www.artaroundadams.org/  1 Million 4 Anna was granted a charity sponsorship, thanks to an anonymous donor
 
6/11 - 24 Hour Golf Tournament in Duluth, GA - 1M4A is a benefactor of this fun 24 hour tourney, raising money for childhood cancer research
 
9/16-17 - see you at CureFest in Washington, DC!!   https://www.curefestusa.org/
 
9/24-25 - 6th Annual Celebration Dinner & Golf Tournament in Dallas
Thank You

The outreach of our mission is extended because of all the wonderful volunteers and supporters. We are very grateful for all who help us in so many ways!
 
Thank you to the 6th Grade Random Acts of Kindness Group at Prince of Peace Catholic School for providing Prayer Jars for two special ewing sarcoma warriors and Busy Books for the children’s hospitals. 

 
Thank you to this awesome team of 5th graders at Christ The King Catholic School who designed, programmed and built a robotic toy for kids in chemo and named it “Anna’s Wish”.

 
Thank you to the JPII Prayer Warriors for welcoming Ashley, Ewing’s survivor, and for supporting Ashley’s Hearts of Hope Valentine project.
 

Thank you Kathy McCollum who shared 1 Million 4 Anna while promoting Childhood Cancer Awareness in Manhattan, IL at the Irish Fest Parade!
 

Thank you to Heather Charre, who organized the “JayBowl” for a second year to honor her son, Jonathan, and to support Anna’s Closest in Chattanooga at Children’s of Erlanger.
 


Amazon Smile

Don't forget! When you're online shopping, keep Amazon Smile in mind. Every time you shop, just go to smile.amazon.com, select 1 Million 4 Anna from the list, and a percentage of your purchase goes to 1 Million 4 Anna! It is that simple! We thank you in advance!! 

 
The 1 Million 4 Anna Foundation was founded in 2012 in loving memory of Anna Lee Basso. 5/10/93-6/8/11.

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